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NVIDIA is reporting that Mac OS X 10.6.7, released a few days ago, removes drivers for high-end NVIDIA Quadro 4000 cards, so machines with these cards will refuse to boot up after installing OS X 10.6.7.
There is an updated driver for OS X 10.6.7 here. The support post is a little vague and doesn't state if the new driver can be installed before updating to 10.6.7 to prevent the issue from occurring, or if it must be installed afterward. If the latter, the article states that you should install a different graphics card in order to boot up to install the new driver, but I'd only advise that if Safe Mode and Target Disk Mode fail.
Update: TUAW is reporting that the NVIDIA support article is inaccurate and that Quadro 4000 machines will boot up just fine but without 3D acceleration and other features. Just install the new driver and these features will be restored.